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Video · 2026-08-12 · 45m · 12 moments

How to find businesses with (almost) zero competition

✦ AI generated

timeline · colored by role

01
Example

Drug testing on monkeys is a massive, consolidated business controlled by a few key players like Charles River Labs.

The speakers discuss the surprisingly large and expensive business of breeding and testing non-human primates for pharmaceutical research, highlighting Charles River Labs' dominance.

transcript

Host: So, basically more than 20% of all drugs are tested on monkeys... Charles River Labs... they work with like 80% of biotech companies... They do 4 billion a year in revenue... They bought a monkey breeding business like a supply like part of the monkey supply chain cuz they were like so dependent on these wild swings. They bought one for $500 million just just to control the supply better to get make sure that they were not going to like lack lack the supply of these these NHPs.

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02
Example

The lab testing monkey business is a massive, hidden industry where a single monkey costs $20,000, China controlled 60% of supply before cutting exports, and Charles River Labs built a $4 billion monopoly serving 80% of biotech companies.

The speakers reveal the surprisingly large and ethically complex business of testing drugs on monkeys, detailing how China's export ban created a supply shock, prices skyrocketed, and Charles River Labs capitalized by building a near-monopoly with $4B in annual revenue.

transcript

Speaker 1: So, basically more than 20% of all drugs are tested on monkeys... each monkey costs Guess how much a monkey costs? >> A thousand? >> Almost 20,000... They used to be two grand a monkey. When COVID happened, prices shot up cuz they needed to test for medicines, vaccines, whatnot. So, it got to 20,000, 50,000 per monkey. And then what happened was at the time China supplied like 60% of the world's what they call NHPs, non-human primates... They just stopped exporting... So, there's this one business called Charles River Labs... They work with like 80% of biotech companies... They do 4 billion a year in revenue... They bought a monkey breeding business like a supply like part of the monkey supply chain cuz they were like so dependent on these wild swings. They bought one for $500 million just just to control the supply better

03
Claim

Everything in the world exists because an entrepreneur created it—nothing is accidental—and the richest people often operate in obscure niches that smart, educated people never hear about.

The speakers reflect on how the podcast has rewired their brains to see that every object has a business behind it, from pencil lead to conveyor belt treads, and that enormous wealth hides in unglamorous, off-the-beaten-path industries.

transcript

Speaker 1: You know, one thing this this podcast has done a lot of for me is it rewired my brain to understand that when I look around the room, nothing is here by accident. Nothing just appeared. You know, like the the little like the lead that goes in this this mechanical pencils. There's a company that makes that. There's a guy who you'll meet on a boat somewhere whose business is just to provide these lead... the world is full of these projects and everywhere... It's always bigger than you think... I sell you know, in a factory where there's like a conveyor belt... the tread of that conveyor conveyor belt. We make the tread... I met a guy who makes the dye that makes the color blue because blue is not really a naturally occurring you know, chem substance you find.

gives example · 1provides context · 1

04
Claim

Every object in the room represents a business created by an entrepreneur, and these hidden industries are often much larger and more profitable than they appear.

The hosts reflect on how every mundane item, from mechanical pencil lead to conveyor belt treads, is the product of a specific, often highly profitable, niche business.

transcript

Host: You know, one thing this this podcast has done a lot of for me is it rewired my brain to understand that when I look around the room, nothing is here by accident. Nothing just appeared. You know, like the the little like the lead that goes in this this mechanical pencils. There's a company that makes that... The world is full of these projects and everywhere... And it's always bigger than you think... And they're just like richer than you'd ever think.

gives example · 3

05
Example

American Express was in the business of verifying soybean oil inventory, a little-known service that nearly bankrupted them during a massive fraud.

The hosts describe the "Salad Oil Scam" where a fraudster filled tanks with water, tricked AmEx into verifying them, and left AmEx on the hook for hundreds of millions.

transcript

Host: I find you had referenced this, but I didn't quite know what you were talking about and I didn't want to ask cuz I didn't want to look stupid, but it's the soybean oil shortage and basically the idea here is that one of Warren Buffett's best trades ever was American Express because at the time there was this whole scheme where basically there was a a scam artist and he realized that he could get loans against his soybean oil inventory... And because American Express was the guarantor, they were the company that promised that the amount of soybean oil promised to the lenders was there, they were the ones who had to pay this massive fine.

06
Claim

There is an arbitrage between what smart people learn about in school and the obscure problems that actually need solving—smart entrepreneurs should deliberately avoid crowded fields and target niches where high-agency people haven't entered yet.

The speakers argue that the biggest business opportunities lie in unglamorous, obscure categories that smart people overlook, because most founders build what they know (like to-do apps) rather than seeking out unfamiliar, low-competition spaces.

transcript

Speaker 1: There's a lot of business in the weird nooks and crannies of the world. There's a lot of money to be made doing things that are just off the beaten path because there's this arbitrage between what smart people learn about in their day-to-day life or school, which is why you'll see a lot of programmers who will build to-do list apps. And, you know, dating apps and things that it's like, what's a problem that every smart person runs into? You simply want to just stay away from that and go into things that they just haven't heard about. They don't know too much about, you know, what I mean? Like, go into a a category that is just not ripe with really smart, you know, high agency people, and you're playing against weak competition.

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07
Mechanism

Noticing small details and patterns is a superpower for entrepreneurs, and most people fail to develop this skill because they dismiss their childhood interests as trivial rather than recognizing them as signals of what they're naturally drawn to.

The speakers discuss how great entrepreneurs and creatives share the ability to notice what others overlook, using examples from Jerry Seinfeld's joke-writing habit to Dan Brown's treasure-hunt novels to argue that childhood interests often contain the seeds of professional greatness.

transcript

Speaker 2: It's the art of noticing... It is actually why comedians, when they get rich and famous, they fall off. Because it's the struggles of the everyday person that led them to an insight... you have to really like create a system where you were going to be exposed to interesting things and a habit of noticing them... pay attention to what you did in your free time... as a kid, you don't really think about what you should do. You just simply think about what you want to do... what happens is we find these things that we're interested in, but we blow we blow them off. We just brush them off as if they're sort of trivial, or meaningless, they are irrelevant, or they're childish.

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08
Mechanism

The path to finding opportunities with low competition is to follow your genuine excitement to the frontier of a field, where you'll discover gaps and tedious problems that nobody else has bothered to solve.

Summarizing Paul Graham's essay, the speakers explain that your interests act as both motor and rudder—driving you forward and steering you toward a unique position at the frontier where gaps and inefficiencies become visible to those who bother to look.

transcript

Speaker 2: Paul Graham wrote this essay called How to Do Great Work... he basically says, 'Look, like here's the formula. You want to first just follow the path of most excitement, so of most interest to you'... let your excitement or your interest be the motor of the boat as well as the rudder... go all the way to the frontier... when you're at the frontier... you notice, oh [__] you got to kind of step over these gaps that exist. People don't know this. They don't do They don't know how to do this... and it's only when you're in the frontier there that you will find the gaps and then you the entrepreneurial step is to just decide to fill one of those.

gives example · 1provides context · 1supports · 1

09
Mechanism

To do great work, follow your excitement to the edge of a field's frontier, where you will find gaps that others have ignored.

The host summarizes Paul Graham's essay "How to Do Great Work," arguing that personal interest acts as both a motivator and a guide to finding less competitive, high-impact problems.

transcript

Host: Paul Graham wrote this essay called How to Do Great Work. And what he describes is like a few steps system... In it, he basically says, 'Look, like here's the formula. You want to first just follow the path of most excitement, so of most interest to you.' ... Let your excitement or your interest be the motor of the boat as well as the rudder. ... Go all the way to the frontier. ... if you get all the way out there, you notice, oh [ __ ] you got to kind of step over these gaps that exist. People don't know this. ... And it's only when you're in the frontier there that you will find the gaps and then you the entrepreneurial step is to just decide to fill one of those.

10
Claim

Enthusiasm is an underrated, high-alpha trait that smart people refuse to cultivate because it feels low-status, but it creates an uncompetitive playing field where you can dominate with minimal effort.

The speakers argue that enthusiasm is one of several traits that matter enormously but that smart people avoid displaying because it seems unsophisticated, creating a wide-open competitive field for those willing to be genuinely excited.

transcript

Speaker 2: Enthusiasm is such an underrated trait. Everybody knows that it's better to work with somebody who's enthusiastic. Everybody knows that enthusiasm is a positive attribute to have, but it's something that smart people feel stupid when they do it. Like it's a low status thing for a smart person to do is be enthusiastic. And you seem sort of like dumb, like a golden retriever. Well, guess what? Everybody wants that person around. We love golden retrievers. And it's actually a very useful trait for going and doing something hard is to have enthusiasm every day versus just being beaten down by the reality of your situation. So there's these like handful of traits that smart people refuse to work on, which makes it like an uncompetitive playing field. You could just go dominate with very little effort.

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11
Mechanism

The things you were obsessed with as a child, if paid attention to and not dismissed, can reveal the work you are uniquely suited and motivated to do.

The hosts argue that childhood hobbies and "rabbit holes" contain the "through line" for your life's work, using Dan Brown's treasure hunts as a key example.

transcript

Host: I do think it's everyone is capable of it, but very few people ever do it. I think there's two two interesting things I can say about this. The first is look into your childhood... So, you know, I got obsessed with one video game. But then I would grow out of that, but then I got obsessed with online poker. ... And I got obsessed with business, and now I'm sort of obsessed with investing. And they're all the same through line, right? ... Dan Brown... when he was a kid, his dad did something really wonderful for him, and sparked this like passion in him. Every Christmas, instead of presents under the tree, his dad would put a treasure map... He paid attention to the things he was interested in loved as a kid.

12
Claim

To find success, you must not only notice your unique interests but also have the shamelessness to pursue them fully, which attracts like-minded collaborators.

Using board game designer Elan Lee as an example, the hosts argue that "letting your freak flag fly" allows you to build expertise in a niche and attracts the right people to your work.

transcript

Host: So just one is one is pay attention to your childhood, notice what you loved then. The second is don't uh sort of brush it off. Don't don't uh you got to be a bit shameless about it... Elan Lee was one of the creators of the Exploding Kittens board game. And he built an enormous ... business in the business of board games and card games... he's just still doing the [ __ ] he loved as a kid... if you do the [ __ ] that's the most to you, you will only attract you'll repel people who want to be at the strip club, and you will attract people who are like you.

provides context · 1

Highlight slides
The Hidden Monkey Testing Industry✦ from: The lab testing monkey business is a massive, hidden industry where a single monkey costs $20,000, China controlled 60% of supply before cutting exports, and Charles River Labs built a $4 billion monopoly serving 80% of biotech companies.Monkey Testing Is a Consolidated, Multi-Billion Dollar Industry✦ from: Drug testing on monkeys is a massive, consolidated business controlled by a few key players like Charles River Labs.Charles River Labs: The Monopoly✦ from: The lab testing monkey business is a massive, hidden industry where a single monkey costs $20,000, China controlled 60% of supply before cutting exports, and Charles River Labs built a $4 billion monopoly serving 80% of biotech companies.Hidden Businesses Are Everywhere✦ from: Every object in the room represents a business created by an entrepreneur, and these hidden industries are often much larger and more profitable than they appear.Bigger and Richer Than You Think✦ from: Every object in the room represents a business created by an entrepreneur, and these hidden industries are often much larger and more profitable than they appear.The Smart-Person Arbitrage✦ from: There is an arbitrage between what smart people learn about in school and the obscure problems that actually need solving—smart entrepreneurs should deliberately avoid crowded fields and target niches where high-agency people haven't entered yet.Where Smart People Build vs. Where Money Is✦ from: There is an arbitrage between what smart people learn about in school and the obscure problems that actually need solving—smart entrepreneurs should deliberately avoid crowded fields and target niches where high-agency people haven't entered yet.
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