GLP-1 drugs are already one of the most powerful longevity interventions available, because they effectively deliver caloric restriction — the only intervention proven in data to extend lifespan — at scale.

When asked about extending lifespan past 100, Oleg argues that GLP-1/obesity drugs are the best longevity drug we already have. Caloric restriction is the only intervention proven to extend lifespan in actual data, and these drugs achieve precisely that pharmacologically. He takes the over on lifespans reaching 125-150 within the room's lifetimes. ✦ AI generated

Oleg Nodelman · All-In Podcast · 2026-06-12 · original ↗

I would take the over on that. In no small part because we already have one of the best longevity drugs out there and folks don't even realize it in the GLP ones and the obesity drugs. So one of the only things that's ever been shown in actual data to extend life is caloric restriction. And that's literally what all the obesity drugs do. So I'm sure half the people in this room are on one of them. And that's just the beginning because it's trained people that you can inject yourself with something and have healthy living through pharmaceuticals. So I think that's only going to continue.

verbatim transcript · starts at 37:49