The biggest enemies of freedom are fear and greed, and you overcome them by imagining the worst thing that can happen to you and making yourself comfortable with it.
Pavel explains that fear and greed are the primary threats to freedom, and the way to resist them is to mentally confront and accept the worst possible outcome, removing the power of fear.
transcript
Pavel Durov: Well, the biggest enemies of freedom are fear and greed. So you make sure that they don't stand in your way. If you imagine the worst thing that can happen to you and then make yourself be comfortable with it. There's nothing more left to be afraid of. So you stand your ground and you remember that it's worth living your life according to the principles that you believe in, even though this life can end up being shorter than a longer life, but lived in slavery.